UA Arthritis Center Director C. Kent Kwoh, MD, along with his team of colleagues from throughout the U.S. and abroad, had his recent work published in the August editions of Arthritis and Rheumatology. The article highlights groundbreaking research based on data from the NIH-funded Osteoarthritis Initiative (OAI) detailing MRI imaging-based trajectory comparing 355 knees that developed radiographic osteoarthritis over time versus those that did not. This work was funded by a grant from the National Institutes of Health awarded to Dr. Kwoh.
The highlights include:
- Specific MRI-detected structural joint damage predicts subsequent radiographically apparent osteoarthritis (OA) of the knee two years later.
- Damage to the meniscus, bone marrow changes, and synovial inflammation are early knee OA pathogenic processes despite the prevailing concept that pathologic cartilage changes are an initiating event.
- Specific early structural changes visible on MRI predicted the later development of radiographic osteoarthritis (OA), a nested case-control study found.
The article has generated international attention, with a recent MedPage Today story shared by the Office of Science Policy, Planning and Communication in the National Institute of Arthritis and Musculoskeletal Skin Diseases/National Institutes of Health.
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